{"id":3831,"date":"2019-03-25T12:15:03","date_gmt":"2019-03-25T11:15:03","guid":{"rendered":"http:\/\/www.dbsv.uninsubria.it\/dbsv\/?page_id=3831"},"modified":"2023-06-01T12:35:28","modified_gmt":"2023-06-01T10:35:28","slug":"immunology-and-general-pathology","status":"publish","type":"page","link":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/?page_id=3831","title":{"rendered":"Immunology and General Pathology"},"content":{"rendered":"<p><a href=\"http:\/\/www.dbsv.uninsubria.it\/dbsv\/wp-content\/uploads\/2019\/03\/hela-cells-544318_1280.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3833 aligncenter\" src=\"http:\/\/www.dbsv.uninsubria.it\/dbsv\/wp-content\/uploads\/2019\/03\/hela-cells-544318_1280-300x226.jpg\" alt=\"\" width=\"462\" height=\"348\" srcset=\"https:\/\/www.dbsv.uninsubria.it\/dbsv\/wp-content\/uploads\/2019\/03\/hela-cells-544318_1280-300x226.jpg 300w, https:\/\/www.dbsv.uninsubria.it\/dbsv\/wp-content\/uploads\/2019\/03\/hela-cells-544318_1280-768x578.jpg 768w, https:\/\/www.dbsv.uninsubria.it\/dbsv\/wp-content\/uploads\/2019\/03\/hela-cells-544318_1280-1024x770.jpg 1024w, https:\/\/www.dbsv.uninsubria.it\/dbsv\/wp-content\/uploads\/2019\/03\/hela-cells-544318_1280.jpg 1280w\" sizes=\"auto, (max-width: 462px) 100vw, 462px\" \/><\/a><\/p>\n<p>Research conducted in the Laboratory of Immunology and General Pathology is focused on the following areas:<\/p>\n<ul>\n<li>Biology of Natural Killer (NK) cells and innate lymphoid cells (ILCs) in solid tumours (prostate, pancreas, colorectal, lung, kidney, breast).<\/li>\n<li>Study of tumour microenvironment and tumour angiogenesis as targets of (immuno)therapy and prevention.<\/li>\n<li>Role of Natural Killer cells, neutrophils and T cells in autoimmune diseases (Grave&#8217;s disease, Hashimoto&#8217;s disease).<\/li>\n<li>Role of immunomodulatory activity of RNASET2 molecule in cancer and autoimmune diseases.<\/li>\n<li>Role of innate immunity (monocytes\/macrophages, neutrophils) and inflammation in cancer and cardiovascular disease (atherosclerosis, diabetes).<\/li>\n<li>Study of immune response in cancer patients, post-SARS-CoV-2 vaccination.<\/li>\n<li>Cancer stem cells (CSCs).<\/li>\n<\/ul>\n<p>Experimental activities involve the use of cell biology (cell lines and primary cultures), biochemistry, and molecular biology approaches. The research group has developed significant experience in &#8216;multiparametric flow cytometry (up to 18 markers simultaneously) applied to immunology.<\/p>\n<p>In addition, the group has a well-established experience in using murine models in biomedical research.<\/p>\n<p><strong>Staff and contacts<\/strong><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Prof. <span style=\"color: #008000;\"><strong><a style=\"color: #008000;\" href=\"https:\/\/www.uninsubria.it\/hpp\/douglas.noonan\" target=\"_blank\" rel=\"noopener noreferrer\">Douglas Noonan<\/a><\/strong><\/span> (associate professor)<\/li>\n<li>Prof. <span style=\"color: #008000;\"><strong><a style=\"color: #008000;\" href=\"https:\/\/www.uninsubria.it\/hpp\/lorenzo.mortara\" target=\"_blank\" rel=\"noopener noreferrer\">Lorenzo Mortara<\/a><\/strong><\/span> (associate professor)<\/li>\n<li>Dr. <a href=\"https:\/\/www.uninsubria.it\/hpp\/antonino.bruno#0\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #008000;\"><strong>Antonio Bruno<\/strong><\/span><\/a> (assistant professor RTD-B)<\/li>\n<li>Dr. <a href=\"https:\/\/www.uninsubria.it\/hpp\/raffaella-maria.bombelli\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #008000;\"><strong>Raffaella Bombelli<\/strong><\/span><\/a> (laboratory technician)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>Find us<\/strong>: Campus Bizzozero; Via Monte Generoso, 71; 21100 Varese; Palazzina rossa ex colonia<\/p>\n<p><a href=\"http:\/\/www.dbsv.uninsubria.it\/dbsv\/?page_id=520\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Website<\/strong><\/a><\/p>\n<p><strong>Keywords:\u00a0<\/strong>Tumor microenvironment, Natural Killer cells, Innate Lymphoid Cells, Neutrophils, Monocytes\/Macrophages, Inflammation, Angiogenesis, Immunotherapy.<br \/>\nERC sectors:LS6_1 Immunit\u00e0 innata; LS4_6 cancro e sue basi biologiche; LS6_12 Basi biologiche dei disturbi legati all&#8217;immunit\u00e0.<\/p>\n<p><strong>Collaborations:\u00a0<\/strong><br \/>\nDr. Matteo Gallazzi, Innate Immunity Laboratory, IRCCS MultiMedica, Milano.<br \/>\nDr. Angelo Naselli, Urology Unit, IRCCS MultiMedica, Milano.<br \/>\nDr. Riccardo Ricotta, Division of Medical Oncology, IRCCS MultiMedica, Milano.<br \/>\nProf. Francesco Bertolini, Laboratory of Hematoncology, European Institute of Oncology (IEO), Milano.<br \/>\nProf. Antonio Inforzato, Humanitas Clinical Institute, Rozzano.<br \/>\nDr. Santiago Gonzales, Institute for Research in Biomedicine (IRB), Universit\u00e0 della Svizzera Italiana, Bellinzona, Svizzera.<br \/>\nProf.ssa Valeria Poli, Department of Molecular Biotechnology and Health Sciences, Universit\u00e0 di Torino, Torino.<br \/>\nDr. Alsessandro Poggi, SSD Molecular Oncology and Angiogenesis, IRCCS Ospedale Policlinico San Martino, 16132 Genova.<br \/>\nDott.ssa Giovanna Chiorino, Tempia Foundation, Biella.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research conducted in the Laboratory of Immunology and General Pathology is focused on the following areas: Biology of Natural Killer (NK) cells and innate lymphoid cells (ILCs) in solid tumours (prostate, pancreas, colorectal, lung, kidney, breast). Study of tumour microenvironment and tumour angiogenesis as targets of (immuno)therapy and prevention. Role of Natural Killer cells, neutrophils &hellip; <a href=\"https:\/\/www.dbsv.uninsubria.it\/dbsv\/?page_id=3831\" class=\"more-link\">Continua a leggere <span class=\"screen-reader-text\">Immunology and General Pathology<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3831","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/pages\/3831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3831"}],"version-history":[{"count":15,"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/pages\/3831\/revisions"}],"predecessor-version":[{"id":4845,"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/pages\/3831\/revisions\/4845"}],"wp:attachment":[{"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}