{"id":3926,"date":"2019-04-01T14:14:19","date_gmt":"2019-04-01T12:14:19","guid":{"rendered":"http:\/\/www.dbsv.uninsubria.it\/dbsv\/?page_id=3926"},"modified":"2023-06-01T15:05:39","modified_gmt":"2023-06-01T13:05:39","slug":"molecular-genetics","status":"publish","type":"page","link":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/?page_id=3926","title":{"rendered":"Molecular Genetics"},"content":{"rendered":"

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Our group aims to study the molecular and genetic bases of human diseases, with a particular interest in studying cancer and in particular lung cancer.<\/p>\n

The two main projects are:<\/p>\n

1. the characterization of PRODH gene regulation and of the role that the encoded enzyme, proline dehydrogenase,\u00a0 plays in the modulation of specific cellular phenotypes. We study how modulation of its expression in human adenocarcinoma cell lines impacts on phenotypes such as cell proliferation, cellular senescence and apoptosis. \u00a0We also aim to study the effect of modulating proline dehydrogenase on the tumour microenvironment and in drug resistance.
\n2. Identification and validation of microRNAs as circulating biomarkers to be applied to screening and early diagnosis of lung cancer. \u00a0For this study, we use droplet digital PCR, but we are also interested in developing novel diagnostic tests to measure microRNA directly in serum and plasma.<\/p>\n

Staff and contacts<\/strong><\/p>\n