{"id":3937,"date":"2019-04-02T10:13:56","date_gmt":"2019-04-02T08:13:56","guid":{"rendered":"http:\/\/www.dbsv.uninsubria.it\/dbsv\/?page_id=3937"},"modified":"2023-06-05T16:05:04","modified_gmt":"2023-06-05T14:05:04","slug":"post-genomics-and-protein-engineering","status":"publish","type":"page","link":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/?page_id=3937","title":{"rendered":"The Protein Factory 2.0"},"content":{"rendered":"<p><a href=\"http:\/\/www.dbsv.uninsubria.it\/dbsv\/wp-content\/uploads\/2019\/04\/mscs-ion-channel-protein-structure-laguna-design-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3936 aligncenter\" src=\"http:\/\/www.dbsv.uninsubria.it\/dbsv\/wp-content\/uploads\/2019\/04\/mscs-ion-channel-protein-structure-laguna-design-2-300x225.jpg\" alt=\"\" width=\"539\" height=\"404\" srcset=\"https:\/\/www.dbsv.uninsubria.it\/dbsv\/wp-content\/uploads\/2019\/04\/mscs-ion-channel-protein-structure-laguna-design-2-300x225.jpg 300w, https:\/\/www.dbsv.uninsubria.it\/dbsv\/wp-content\/uploads\/2019\/04\/mscs-ion-channel-protein-structure-laguna-design-2-768x575.jpg 768w, https:\/\/www.dbsv.uninsubria.it\/dbsv\/wp-content\/uploads\/2019\/04\/mscs-ion-channel-protein-structure-laguna-design-2.jpg 900w\" sizes=\"auto, (max-width: 539px) 100vw, 539px\" \/><\/a><\/p>\n<p>The main focal points of the research activity of the Protein Factory 2.0 are:<\/p>\n<p>&#8211; the investigation of enzymes and whole metabolic pathways, in particular the ones involved in the metabolism of D-amino acids, their regulation and dysfunctions related to relevant human diseases;<br \/>&#8211; the analysis of D-amino acids in human serum and fluids, to validate alterations in their levels as early biomarkers in Alzheimer\u2019s disease;<br \/>&#8211; the production of improved variants (generated by protein engineering) of recombinant proteins useful in several areas of biotechnology: human health (protein therapeutics), bio-based industry (biocatalysis), biorefineries (lignin valorization), bioremediation and circular economy processes (removal of pesticides, plastics and toxins);<br \/>&#8211; the analysis of paclitaxel levels in human blood after drug-coated balloon treatment.<\/p>\n<p><strong>Staff and contacts<\/strong><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>Prof. <span style=\"color: #008000;\"><strong><a style=\"color: #008000;\" href=\"https:\/\/www.uninsubria.it\/hpp\/loredano.pollegioni\" target=\"_blank\" rel=\"noopener noreferrer\">Loredano Pollegioni<\/a><\/strong><span style=\"color: #000000;\"> (full professor)<\/span><\/span><\/li>\n<li>Prof. <span style=\"color: #008000;\"><strong><a style=\"color: #008000;\" href=\"https:\/\/www.uninsubria.it\/hpp\/luciano.piubelli\" target=\"_blank\" rel=\"noopener noreferrer\">Luciano Piubelli<\/a><\/strong><span style=\"color: #000000;\"> (associate professor)<\/span><\/span><\/li>\n<li>Prof. <span style=\"color: #008000;\"><strong><a style=\"color: #008000;\" href=\"https:\/\/www.uninsubria.it\/hpp\/gianluca.molla\" target=\"_blank\" rel=\"noopener noreferrer\">Gianluca Molla<\/a> <\/strong><span style=\"color: #000000;\">(associate professor)<\/span><\/span><\/li>\n<li>Prof. <span style=\"color: #008000;\"><strong><a style=\"color: #008000;\" href=\"https:\/\/www.uninsubria.it\/hpp\/silvia.sacchi\" target=\"_blank\" rel=\"noopener noreferrer\">Silvia Sacchi<\/a> <\/strong><span style=\"color: #000000;\">(associate professor)<\/span><\/span><\/li>\n<li>Dr. <span style=\"color: #008000;\"><strong><a style=\"color: #008000;\" href=\"https:\/\/www.uninsubria.it\/hpp\/elena.rosini\" target=\"_blank\" rel=\"noopener noreferrer\">Elena Rosini<\/a><\/strong><span style=\"color: #000000;\"> (researcher)<\/span><\/span><\/li>\n<li>Dr. <span style=\"color: #008000;\"><strong><a style=\"color: #008000;\" href=\"https:\/\/www.uninsubria.it\/hpp\/laura.caldinelli\" target=\"_blank\" rel=\"noopener noreferrer\">Laura Caldinelli<\/a><\/strong><span style=\"color: #000000;\"> (researcher)<\/span><\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>Find us:<\/strong> Campus Bizzozero; Via Dunant, 3; 21100 Varese; yellow floor<\/p>\n<p><strong><a href=\"https:\/\/www.theproteinfactory2.it\/\" target=\"_blank\" rel=\"noopener noreferrer\">Group website<\/a><\/strong><\/p>\n<p><strong>Keywords<\/strong>: D-amino acids; recombinant proteins; protein engineering; neuromodulation; biocatalysis; biorefineries; biosensors; structural bioinformatics; enzymology; lignin valorization, plastic degradation<\/p>\n<p><strong>ERC sectors<\/strong>: LS1_2 general biochemistry and metabolism, LS1_5 protein synthesis, modification and turnover, LS1_11 biochemistry and molecular mechanism of signal transduction, LS9_1 applied genetic engineering, transgenic organisms, recombinant proteins, biosensors, LS9_9 applied biotechnologies, bioreactors, applied microbiology, LS5_2 neurophysiology.<\/p>\n<p><strong>Collaborations<\/strong>:\u00a0Ca&#8217; Foscari University of Venice; Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; CMIC, Polytechnic of Milan; CNR-IRSA, Water Research Institute, Verbania; Cryo-EM Lab, Dept. of Biosciences, University of Milan; DAAIR, D-Amino Acid International Research Center, Gerenzano; Dept. of Medicine and Surgery, University of Insubria, Varese; Institute of Sciences of Food Production (ISPA-CNR), Bari; IRCCS Galeazzi Orthopedic Institute, Milan; Lab of Behavioural Neuroscience, Ceinge Biotecnologie Avanzate, Naples; LuMIn, Universit\u00e9 Paris-Saclay, CNRS, ENS Paris-Saclay, Gif-sur-Yvette, France; Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; McGill University, Montreal, Quebec, Canada; Neurology Unit and Vascular Surgery Unit, Circolo and Fondazione Macchi University Teaching Hospital, Varese; University of Campania &#8220;Luigi Vanvitelli&#8221;, Caserta; University of Massachusetts Medical School, Worcester, MA, USA; University of Milan; University of Milan-Bicocca; University of Naples Federico II; University of Parma; University of Pavia; University of Rome &#8220;Tor Vergata&#8221;.<\/p>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The main focal points of the research activity of the Protein Factory 2.0 are: &#8211; the investigation of enzymes and whole metabolic pathways, in particular the ones involved in the metabolism of D-amino acids, their regulation and dysfunctions related to relevant human diseases;&#8211; the analysis of D-amino acids in human serum and fluids, to validate &hellip; <a href=\"https:\/\/www.dbsv.uninsubria.it\/dbsv\/?page_id=3937\" class=\"more-link\">Continua a leggere <span class=\"screen-reader-text\">The Protein Factory 2.0<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3937","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/pages\/3937","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3937"}],"version-history":[{"count":8,"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/pages\/3937\/revisions"}],"predecessor-version":[{"id":4948,"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=\/wp\/v2\/pages\/3937\/revisions\/4948"}],"wp:attachment":[{"href":"https:\/\/www.dbsv.uninsubria.it\/dbsv\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}