2026

  1. Yushchuk O, Rückert-Reed C, Busche T, Marinelli F, Kalinowski J. Updated sequence of ramoplanin biosynthetic gene cluster from Actinoplanes ramoplaninifer ATCC 33,076. J Appl Genet. 2026 Jan 7. doi: 10.1007/s13353-025-01035-6. Epub ahead of print. PMID: 41499035.

2025

  1. Mellere, L.; Bava, A.; Armengaud, J.; Berini, F.; Marinelli, F.; Varese, G.C.; Spina, F.; Beltrametti, F. Unravelling the Potential of Fungal Division of Labour in the Laccase Producer Coriolopsis trogii MUT3379 Through Protoplast Formation and Regeneration. J. Fungi 2025, 11, 890. https://doi.org/10.3390/jof11120890
  2. Yushchuk O, Berini F, Zhong L, Rückert-Reed C, Bernasconi E, Bartolone L, Busche T, Kalinowski J, Süssmuth RD, Marinelli F. A rare peptide scaffold in kineomicins, the glycopeptide antibiotics produced by Actinokineospora auranticolor DSM 44650. Commun Chem. 2025 May 3;8(1):134. doi: 10.1038/s42004-025-01534-x. PMID: 40319198; PMCID: PMC12049478.
  3. Bisaccia M, Berini F, Marinelli F, Binda E. Emerging Trends in Antimicrobial Resistance in Polar Aquatic Ecosystems. Antibiotics (Basel). 2025 Apr 10;14(4):394. doi: 10.3390/antibiotics14040394. PMID: 40298543; PMCID: PMC12024378.
  4. Melissa B, Elisa B, Gabriella C, Maurizio A, Ombretta DA, Andrea DC, Eckert EM, Flavia M. Bacterial Diversity of Marine Biofilm Communities in Terra Nova Bay (Antarctica) by Culture-Dependent and -Independent Approaches. Environ Microbiol. 2025 Feb;27(2):e70045. doi: 10.1111/1462-2920.70045. PMID: 39895061; PMCID: PMC11788576.

2024

  1. Stepanyshyn A, Rückert-Reed C, Busche T, Yaruta B, Andreo-Vidal A, Marinelli F, Kalinowski J, Yushchuk O. Complete Genome Assembly of Amycolatopsis bartoniae DSM 45807T Allows the Characterization of a Novel Glycopeptide Biosynthetic Gene Cluster. Genes (Basel). 2024 Dec 22;15(12):1651. doi: 10.3390/genes15121651. PMID: 39766918; PMCID: PMC11727664.
  2. Montali A, Berini F, Gamberoni F, Armenia I, Saviane A, Cappellozza S, Gornati R, Bernardini G, Marinelli F, Tettamanti G. In vivo efficacy of a nanoconjugated glycopeptide antibiotic in silkworm larvae infected by Staphylococcus aureus. Insects 2024, 15, 886. https://doi.org/10.3390/insects15110886
  3. Yushchuk, O.; Zhukrovska, K.; Binda, E.; Marinelli, F. Unraveling the Biosynthetic Logic Behind the Production of Ramoplanin and Related Lipodepsipeptide Antibiotics. Fermentation 2024, 10, 544. https://doi.org/10.3390/fermentation10110544
  4. Mellere L, Bellasio M, Berini F, Marinelli F, Armengaud J, Beltrametti F. Coriolopsis trogii MUT3379: A novel cell factory for high-yield laccase production. Fermentation 2024, 10:376. doi: 10.3390/fermentation10070376.
  5. Miškovská A, Michailidu J, Kolouchová IJ, Barone L, Gornati R, Montali A, Tettamanti G, Berini F, Marinelli F, Masák J, Čejková A, Maťátková O. Biological activity of silver nanoparticles synthesized using viticultural waste. Microb Pathog. 2024 Mar 12;190:106613. doi: 10.1016/j.micpath.2024.106613. Epub ahead of print. PMID: 38484919.
  6. Berini F, Montali A, Liguori R, Venturini G, Bonelli M, Shaltiel-Harpaz L, Reguzzoni M, Siti M, Marinelli F, Casartelli M, Tettamanti G. Production and characterization of Trichoderma asperellum chitinases and their use in synergy with Bacillus thuringiensis for lepidopteran control. Pest Manag Sci. 2024 Feb 26. doi: 10.1002/ps.8045. Epub ahead of print. PMID: 38407453.
  7. Yushchuk O, Binda E, Rückert-Reed C, Berini F, Fedorenko V, Kalinowski J, Marinelli F. Actinoplanes oblitus sp. nov., producing the glycopeptide antibiotic A477. Int J Syst Evol Microbiol. 2024 Jan;74(1). doi: 10.1099/ijsem.0.006225. PMID: 38190227.
  8. Zhukrovska K, Binda E, Fedorenko V, Marinelli F, Yushchuk O. The Impact of Heterologous Regulatory Genes from Lipodepsipeptide Biosynthetic Gene Clusters on the Production of Teicoplanin and A40926. Antibiotics 2024, 13, 115. https://doi.org/10.3390/antibiotics13020115

2023

  1. Bisaccia M, Binda E, Rosini E, Caruso G, Dell’Acqua O, Azzaro M, Laganà P, Tedeschi G, Maffioli EM, Pollegioni L, Marinelli F. A novel promising laccase from the psychrotolerant and halotolerant Antarctic marine Halomonas sp. M68 strain. Front Microbiol. 2023 Feb 10;14:1078382. doi: 10.3389/fmicb.2023.1078382. PMID: 36846806; PMCID: PMC9950745.
  2. Andreo-Vidal, A.; Yushchuk, O.; Marinelli, F.; Binda, E. Cross-Talking of Pathway-Specific Regulators in Glycopeptide Antibiotics (Teicoplanin and A40926) Production. Antibiotics 2023, 12, 641. https://doi.org/10.3390/antibiotics12040641

2022

  1. Yushchuk, O.; Zhukrovska, K.; Ostash, B.; Fedorenko, V.; Marinelli, F. Heterologous Expression Reveals Ancient Properties of Tei3—A VanS Ortholog from the Teicoplanin Producer Actinoplanesteichomyceticus. Int. J. Mol. Sci. 2022, 23, 15713. https://doi.org/10.3390/ijms232415713
  2. Yushchuk O, Binda E, Fedorenko V, Marinelli F. Occurrence of vanHAX and Related Genes beyond the Actinobacteria Phylum. Genes. 2022; 13(11):1960. https://doi.org/10.3390/genes13111960
  3. Montali A, Berini F, Saviane A, Cappellozza S, Marinelli F, Tettamanti G. A Bombyx mori Infection Model for Screening Antibiotics against Staphylococcus epidermidis. Insects. 2022 Aug 19;13(8):748. doi: 10.3390/insects13080748.
  4. Hoyos P, Perona A, Bavaro T, Berini F, Marinelli F, Terreni M, Hernáiz MJ. Biocatalyzed Synthesis of Glycostructures with Anti-infective Activity. Acc Chem Res. 2022 Sep 6;55(17):2409-2424. doi: 10.1021/acs.accounts.2c00136.
  5. Yushchuk O, Zhukrovska K, Berini F, Fedorenko V, Marinelli F. Genetics Behind the Glycosylation Patterns in the Biosynthesis of Dalbaheptides. Front Chem. 2022 Mar 24;10:858708. doi: 10.3389/fchem.2022.858708.
  6. Berini F, Orlandi V, Gornati R, Bernardini G, Marinelli F. Nanoantibiotics to fight multidrug resistant infections by Gram-positive bacteria: hope or reality? Biotechnol Adv. 2022 Jul-Aug;57:107948. doi: 10.1016/j.biotechadv.2022.107948. Epub 2022 Mar 23. PMID: 35337933.
  7. Mellere L., Bava A., Capozzoli C, Branduardi P, Berini F, Beltrametti F (2022). Strain improvement and strain maintenance revisited. The use of Actinoplanes teichomyceticus ATCC 31121 protoplasts in the identification of candidates for enhanced teicoplanin production. Antibiotics, 11(1), 24. doi: 10.3390/antibiotics11010024

2021

  1. Andreo-Vidal A, Binda E, Fedorenko V, Marinelli F, Yushchuk O. (2021).  Genomic Insights into the Distribution and Phylogeny of Glycopeptide Resistance Determinants within the Actinobacteria Phylum. Antibiotics (Basel). 10(12):1533. doi: 10.3390/antibiotics10121533
  2. Berini F, Orlandi VT, Gamberoni F, Martegani E, Armenia I, Gornati R, Bernardini G, Marinelli F (2021). Antimicrobial activity of nanoconjugated glycopeptide antibiotics and their effect onStaphylococcus aureus biofilm. Front Microbiol, 12, 657431. doi: 10.3389/fmicb.2021.657431.
  3. Martini MC, Berini F, Ausec L, Casciello C, Vacca C, Pistorio M, Lagares A, Mandic-Mulec I, Marinelli F, Del Papa F (2021). Identification and characterization of a novel plasmid-encoded laccase-like multicopper oxidase from Ochrobactrum sp. BF15 isolated from an on-farm bio-purification system. Food Tech Biotech, 59(4), 519-529. doi: 10.17113/ftb.59.04.21.7253.
  4. Binda, E., Berini, F., Marinelli, F., Bava, A., Beltrametti, F. (2021) Heterogeneous A40926 Self-Resistance Profile in Nonomuraea gerenzanensis Population Informs Strain Improvement. Fermentation 7, 140. doi.org/10.3390/fermentation7030140
  5. Jezkova Z, Binda E, Potocar T, Marinelli F, Halecky M, Branyik T. (2021) Laboratory scale cultivation of Salinispora tropica in shake flasks and mechanically stirred bioreactors. Biotechnol Lett. doi: 10.1007/s10529-021-03121-1. Epub ahead of print. PMID: 34003399.
  6. Yushchuk O, Vior NM, Andreo-Vidal A, Berini F, Rückert C, Busche T, Binda E, Kalinowski J, Truman AW, Marinelli F. (2021)  Genomic-Led Discovery of a Novel Glycopeptide Antibiotic by Nonomuraea coxensis DSM 45129. ACS Chem Biol.  doi: 10.1021/acschembio.1c00170. Epub ahead of print. PMID: 33913701.
  7. Marinelli F, Alifano P, Landini P, Visca P. (2021) Editorial: XXXIII SIMGBM Congress 2019 – Antimicrobials and Host-Pathogen Interactions. Front. Microbiol. https://doi.org/10.3389/fmicb.2021.67251.

2020

  1. Berini F, Marinelli F., Binda E. (2020) Streptomycetes: Attractive Hosts for Recombinant Protein Production. Front. Microbiol 11:1958. doi: 10.3389/fmicb.2020.01958.
  2. Dalmastri C, Gastaldo L, Berini F, Marinelli F, Marcone GL. (2020). Description of the bacterial RNA polymerase inhibitor GE23077-producer Actinomadura sp. NRRL B-65521T as Actinomadura lepetitiana sp. nov. Int. J. Syst. Evol. Microbiol. 70(8):4782-4790. doi: 10.1099/ijsem.0.004348
  3. Yushchuk O, Binda E, Marinelli F. (2020) Glycopeptide Antibiotic Resistance Genes: Distribution and Function in the Producer Actinomycetes. Front. Microbiol doi.org/10.3389/fmicb.2020.01173.
  4. Montali A, Berini F, Brivio MF, Mastore M, Saviane A, Cappellozza S,Marinelli F, Tettamanti G. (2020) A Silkworm Infection Model for In Vivo Study of Glycopeptide Antibiotics. Antibiotics (Basel). 9:E300. doi: 10.3390/antibiotics9060300.
  5. Yushchuk O, Ostash B, Truman AW, Marinelli F, Fedorenko V. (2020) Teicoplanin biosynthesis: unraveling the interplay of structural, regulatory, and resistance genes. Appl Microbiol Biotechnol. doi: 10.1007/s00253-020-10436-y. Epub ahead of print. PMID: 32076781.
  6. Yushchuk O, Vidal A-A, Marcone GL, Bibb M, Marinelli F, Binda E. (2020) New Molecular Tools for Regulation and Improvement of A40926 Glycopeptide Antibiotic Production in Nonomuraea gerenzanensis ATCC 39727.Front. Microbiol. 11:8. doi: 10.3389/fmicb.2020.00008.
  7. Yushchuk O, Homoniuk V, Ostash B, Marinelli F, Fedorenko V. (2020). Genetic insights into the mechanism of teicoplanin self-resistance in Actinoplanes teichomyceticus. J. Antibiot. 73:255-259 doi: 10.1038/s41429-019-0274-9.
  8. Yushchuk O, Homoniuk V, Datsiuk Y, Ostash B, Marinelli F, Fedorenko V. (2020) Development of a gene expression system for the uncommon actinomycete Actinoplanes rectilineatus NRRL B-16090.J Appl Genet. doi: 10.1007/s13353-019-00534-7. 

2019

  1. Marcone GL, Binda E, Rosini E, Abbondi M, Pollegioni L. (2019) Antibacterial Properties of D-Amino Acid Oxidase: Impact on the Food Industry. Front Microbiol. 10:2786.

  2. F. Berini, M. Casartelli, A. Montali, M. Reguzzoni, G. Tettamanti, F. Marinelli. (2019) Metagenome-Sourced Microbial Chitinases as Potential Insecticide Proteins. Front Microbiol. 10:1358.

  3. O. Yushchuk, L. Horbal, B. Ostash, F. Marinelli, W. Wohlleben, E. Stegmann, V. Fedorenko. (2019) Regulation of teicoplanin biosynthesis: refining the roles of tei cluster-situated regulatory genes. Appl Microbiol Biotechnol. 103(10):4089-4102.

2018

  1. I. Armenia, G.L. Marcone, F. Berini, V.T. Olandi, C. Pirrone, E. Martegani, R. Gornati , G. Bernardini, F. Marinelli. (2018) Magnetic Nanoconjugated Teicoplanin: A Novel Tool for Bacterial Infection Site Targeting.. Front Microbiol. 9:2270. 
  2. E. Binda, P. Cappelletti, F. Marinelli, G.L. Marcone. (2018) Specificity of Induction of Glycopeptide Antibiotic Resistance in the Producing Actinomycetes. Antibiotics (Basel). 25(2). https://doi: 10.3390/antibiotics7020036 
  3. G.L. Marcone, E. Binda, F. Berini, F. Marinelli. (2018) Old and new glycopeptide antibiotics: From product to gene and back in the post-genomic era. Biotechnol Adv. 36(2):534-554. https//doi: 10.1016/j.biotechadv.2018.02.009.
  4. F. Berini, M. Verce, L. Ausec, E. Rosini, F. Tonin, L. Pollegioni, I. Mandic-Mulec. (2018). Isolation and characterization of a heterologously expressed bacterial laccase from the anaerobe Geobacter metallireducens. Appl Microbiol Biotechnol. 102(5):2425-2439  https://doi.org/10.1007/s00253-018-8785-z
  5. F. Berini, C. Katz, N. Gruzdev, M. Casartelli, G. Tettamanti, F. Marinelli. (2018) Microbial and viral chitinases: Attractive biopesticides for integrated pest management. Biotechnol Adv. 2018 May – Jun;36(3):818-838. https://doi.org/ 10.1016/j.biotechadv.2018.01.002

2017

  1. F. Berini, C. Casciello, G.L. Marcone, F. Marinelli. (2017) Metagenomics: novel enzymes from nonculturable microbes. FEMS Microbiol Lett. 364(21) https://doi.org/10.1093/femsle/fnx211
  2. G.L Marcone, E. Binda, M. Reguzzoni, L. Gastaldo, C. Dalmastri, F. Marinelli. (2017) Classification of Actinoplanes sp. ATCC 33076, an actinomycete that produces the glycolipodepsipeptide antibiotic ramoplanin, as Actinoplanes ramoplaninifer sp. nov. Int J Syst Evol Microbiol. 67(10):4181-4188. 10.1099/ijsem.0.002281
  3. L. Ausec, F. Berini, C. Casciello, M.S. Cretoiu, J.D. van Elsas, F. Marinelli, I. Mandic-Mulec. (2017). The first acidobacterial laccase-like multicopper oxidase revealed by metagenomics shows high salt and thermo-tolerance. Appl Microbiol Biotechnol. 101(15):6261-6276.  https://doi.org/10.1007/s00253-017-8345-y
  4. F. Berini, I. Presti, F. Beltrametti, M. Pedroli, K.J. Vårum, L. Pollegioni, S. Sjöling, F. Marinelli. (2017). Production and characterization of a novel antifungal chitinase identified by functional screening of a suppressive-soil metagenome. Microb. Cell. Fact. 16:16. http://dx.doi.org/10.1186/s12934-017-0634-8
  5. C. Casciello, F. Tonin, F. Berini, E. Fasoli, F. Marinelli, L. Pollegioni, E. Rosini. (2017). A valuable peroxidase activity from the novel species Nonomuraea gerenzanensis growing on alkali lignin. Biotechnol Rep. 13: 49-57.  http://dx.doi.org/10.1016/j.btre.2016.12.005

2016

  1. E. Binda, L. Carrano, G.L. Marcone, F. Marinelli. (2016). Extraction and Analysis of Peptidoglycan Cell Wall Precursors. Methods Mol Biol.1440:153-70.
  2. C. Dalmastri, L. Gastaldo, G.L. Marcone, E. Binda, T. Congiu, F. Marinelli. (2016). Classification of Nonomuraea sp. ATCC 39727, an actinomycete that produces the glycopeptide antibiotic A40926, as Nonomuraea gerenzanensis sp. nov. Int J Syst Evol Microbiol. 66(2):912-21.
  3. B. Rioseras, P. Yagüe, M.T. López-García, N. Gonzalez-Quiñonez, E. Binda, F. Marinelli, A. Manteca. (2016). Characterization of SCO4439, a D-alanyl-D-alanine carboxypeptidase involved in spore cell wall maturation, resistance, and germination in Streptomyces coelicolor. Sci Rep. 6:21659.
  4. F. Berini, S. Caccia, E. Franzetti, T. Congiu, F. Marinelli, M. Casartelli, G. Tettamanti. (2016). Effects of Trichoderma viride chitinases on the peritrophic matrix of Lepidoptera. Pest Manag Sci. 72(5):980-9.

2015

  1. A. Gallazzi, B. Branska, F. Marinelli, P. Patakova. (2015). Continuous production of n-butanol by Clostridium pasteurianum DSM 525 using suspended and surface-immobilized cells. J Biotechnol. 20;216:29-35.
  2. L. Carrano, M. Abbondi, P. Turconi, G. Candiani, F. Marinelli. (2015). A Novel Microbisporicin Producer Identified by Early Dereplication during Lantibiotic Screening. Biomed Res Int. 2015;2015:419383.
  3. F. Marinelli, O. Genilloud, V. Fedorenko, E.Z. Ron. (2015) Specialized Bioactive Microbial Metabolites: From Gene to Product. Biomed Res Int. 2015:276964.
  4. V. Fedorenko, O. Genilloud, L. Horbal, G.L. Marcone, F. Marinelli, Y. Paitan, E.Z. Ron. (2015). Antibacterial Discovery and Development: From Gene to Product and Back. Biomed Res Int. 2015:591349.
  5. M.S. Cretoiu, F. Berini, A.M. Kielak, F. Marinelli, J.D. van Elsas JD. (2015). A novel salt-tolerant chitobiosidase discovered by genetic screening of a metagenomic library derived from chitin-amended agricultural soil. Appl Microbiol Biotechnol. 99(19):8199-215.

2014

  1.  E. Binda, F. Marinelli, G. L. Marcone (2014). Old and New Glycopeptide Antibiotics: Action and Resistance. Antibiotics3: 572-594;
  2. L. Horbal, A. Kobylyanskyy, A.W. Truman, N. Zaburranyi, B. Ostash, A. Luzhetskyy, F. Marinelli, V. Fedorenko (2014). The pathway-specific regulatory genes, tei15* and tei16*, are the master switches of teicoplanin production in Actinoplanes teichomyceticus. Appl Microbiol Biotechnol.98: 9295-309;
  3. C. Temporini, T. Bavaro, S. Tengattini, I. Serra, G. Marrubini, E. Calleri, F. Fasanella, L. Piubelli, F. Marinelli, L. Pollegioni, G. Speranza, G. Massolini, M. Terreni (2014). Liquid chromatography-mass spectrometry structural characterization of neo glycoproteins aiding the rational design and synthesis of a novel glycovaccine for protection against Tuberculosis. J Chromatogr A. 9673: 01456-3;
  4. G.L. Marcone, E. Binda, L. Carrano, M. Bibb, F. Marinelli (2014). Relationship between glycopeptide production and resistance in the actinomycete Nonomuraea sp. ATCC 39727. Antimicrob Agents Chemother.58:5191-201;
  5. J. Tevino, C. Bayon, A. Ardà, F. Marinelli, R. Gandolfi, F. Molinari, J Jimenez-Barbero, M. J. Hernaiz (2014). New insights into glycopeptide antibiotic binding to cell wall precursors using SPR and NMR spectroscopy. Chem Eur. J. 20: 1-11;
  6. G.L. Marcone, F. Marinelli (2014). Glycopeptides: an old but up-to-date successful antibiotic class” Chapter 5. In Marinelli F, Genilloud O. Antimicrobials New and Old Molecules in the Fight Against Multi-resistant Bacteria. vol. Unico, p. 85-107, Springer , ISBN: 9783642399688;
  7. H.A. Kirst, F. Marinelli (2014). Aminoglycoside antibiotics. Chapter 10. In: Marinelli F, Genilloud O. Antimicrobials New and Old Molecules in the Fight Against Multi-resistant Bacteria. vol. Unico, p. 193-207, Spinger, ISBN: 9783642399688;

2013

  1. E. Binda, GL. Marcone, F. Berini, L. Pollegioni, F. Marinelli (2013). Streptomyces spp. as efficient expression system for a D,D-peptidase/D,D-carboxypeptidase involved in glycopeptide antibiotic resistance. BMC Biotechnol. 13:24;
  2. L. Piubelli, M. Campa, C. Temporini, E. Binda, F. Mangione, M. Amicosante, M. Terreni, F. Marinelli, L. Pollegioni (2013). Optimizing Escherichia coli as a protein expression platform to produce Mycobacterium tuberculosis immunogenic proteins. Microb Cell Fact. 12:115;
  3. K. Hjort, I. Presti, A. Elväng, F. Marinelli and S. Sjöling (2013). Bacterial chitinase with phytopathogen control capacity from suppressive soil revealed by functional metagenomics. Appl. Microbiol. Biotechnol. 98: 2819–2828;
  4. L. Horbal, A. Kobylyanskyy, O. Uschuck, N. Zaburannyi, A. Luzhetskyy, B. Ostash, F. Marinelli, V. Fedorenko (2013). Evaluation of heterologous promoters for genetic analysis of Actinoplanes teichomyceticus – producer of teicoplanin, drug of last defense. Journal of Biotechnology. 168: 367-72;

2012

  1. R. Gandolfi, F. Marinelli, E. Ragg, D. Romano, F. Molinari (2012). Chemoenzymatic deacylation of ramoplanin. Bioorg Med Chem Lett. 22(16):5283-7;
  2. E. Binda, GL. Marcone, L. Pollegioni, F. Marinelli (2012). Characterization of VanYn, a novel D,D-peptidase/D,D-carboxypeptidase involved in glycopeptide antibiotic resistance in Nonomuraea sp. ATCC 39727. FEBS J. 279(17):3203-13;
  3. F. Marinelli, F. Molinari (2012). “Las fermentaciones en al produciòn de metabolitos secundarios de interés farmacéutico” In J.M. Sànchez Montero, F. Ortega Ortiz de Apodaca, A. Doadrio Villarejo. Monografìa XXXV: Biocatàlisis aplicada a la obtenciòn de fàrmacos y productos de alto valor añadido. p. 61-104, Madrid: Real Academia Nacional de Farmacia, ISBN: 9788493817275;