Publications

CELL DEATH AND REGENERATION IN INSECT DEVELOPMENT

– Wu W., Li K., Guo S., Xu J., Ma Q., Li S., Xu X., Huang Z., Zhong Y., Tettamanti G., Cao Y., Li S. and Tian S., 2021. P300/HDAC1 regulates the acetylation/deacetylation and autophagic activities of LC3/Atg8–PE ubiquitin-like system. Cell Death Discovery, 7: 128 (Full text)

– Klionsky D.J.,…..Bruno D.,…..Tettamanti G.,…..Tong C.K., 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17: 1-382 (Abstract)

– Wu W., Luo M., Li K., Dai Y., Yi H., Zhong Y., Cao Y., Tettamanti G. and Tian L., 2021. Cholesterol derivatives induce dephosphorylation of the histone deacetylases Rpd3/HDAC1 to upregulate autophagy. Autophagy, 17: 512-528 (Abstract)

– Tettamanti G. and Casartelli M., 2019. Cell death during complete metamorphosis. Philosophical Transactions of the Royal Society of London – B Biological Sciences, 374: 20190065 (Abstract)

– Caccia S., Casartelli M. and Tettamanti G., 2019. The amazing complexity of insect midgut cells: types, peculiarities, and functions. Cell & Tissue Research, 377: 505-525 (Abstract)

– Tettamanti G., Carata E, Montali A, Dini L. and Fimia G.M., 2019. Autophagy in development and regeneration: role in tissue remodelling and cell survival. The European Zoological Journal, 86: 113-131

– Montali A., Casartelli M., Bruno D., Grimaldi A. and Tettamanti G., 2019. Methods for monitoring autophagy in silkworm organs. Methods in Molecular Biology, 1854: 159-174 (Abstract)

– Montali A., Romanelli D., Cappellozza S., Grimaldi A., de Eguileor M. and Tettamanti G., 2017. Timing of autophagy and apoptosis during posterior silk gland degeneration in Bombyx mori. Arthropod Structure & Development, 46: 518-528 (Abstract)

– Romanelli D., Casartelli M., Cappellozza S., de Eguileor M. and Tettamanti G., 2016. Roles and regulation of autophagy and apoptosis in the remodelling of the lepidopteran midgut epithelium during metamorphosis. Scientific Reports, 6: 32939 (Abstract) 

– Franzetti E., Casartelli M., D’Antona P., Montali A., Romanelli D., Cappellozza S., Caccia S., Grimaldi A., de Eguileor M. and Tettamanti G., 2016. Midgut epithelium in molting silkworm: a fine balance among cell growth, differentiation, and survival. Arthropod Structure & Development, 45: 368-379 (Abstract)

– Klionsky D.J.,………Tettamanti G.,…………Zughaier S.M., 2016. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12: 1-222 (Abstract)

– Kannan M., Aathmanathan V.S., Saravanakumar M., Jaleel A., Romanelli D., Tettamanti G. and Krishan M., 2016. Proteomic study of the silkworm midgut during larval-pupal transition. Invertebrate Survival Journal, 13: 191-204 (Free full text)

– Franzetti E., Romanelli D., Caccia S., Cappellozza S., Congiu T., Rajagopalan M., Grimaldi A., de Eguileor M., Casartelli M. and Tettamanti G., 2015. The midgut of the silkmoth Bombyx mori is able to recycle molecules derived from degeneration of the larval midgut. Cell & Tissue Research, 361: 509-528 (Abstract)

– Romanelli D., Casati B., Franzetti E. and Tettamanti G., 2014. A molecular view of autophagy in Lepidoptera. BioMed Research International, 2014: 902315 (Free full text)

– Franzetti E., Romanelli D. and Tettamanti G., 2014. The key role of autophagy and its relationship with apoptosis in lepidopteran larval midgut remodeling. In -Autophagy: cancer, other pathologies, inflammation, immunity, infection, and aging (vol 3)- (Ed M.A. Hayat), pp 333-349. Elsevier, Amsterdam

– Liu H., Jia Q., Tettamanti G. and Li S., 2013. Balancing crosstalk between 20-hydroxyecdysone-induced autophagy and caspase activity in the fat body during Drosophila larval-prepupal transition. Insect Biochemistry & Molecular Biology, 43: 1068-1078 (Abstract)

– Casati B., Terova G., Cattaneo A.G., Rimoldi S., Franzetti E., de Eguileor M. and Tettamanti G., 2012. Molecular cloning, characterization and expression analysis of ATG1 in the silkworm, Bombyx mori. Gene, 511: 326-337 (Abstract)

– Klionsky D.J.,………Tettamanti G.,…………Zuckerbraun B., 2012. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8: 1-100 (Abstract)

– Franzetti E., Huang Z., Shi Y., Deng X., Li J., Li Q., Yang W., Zeng W., Casartelli M., Deng H., Cappellozza S., Grimaldi A., Xia Q., Feng Q., Cao Y. and Tettamanti G., 2012. Autophagy precedes apoptosis during the remodeling of silkworm larval midgut. Apoptosis, 17: 305-324 (Abstract)

– Li Q., Zheng S., Liu L., Tettamanti G., Cao Y. and Feng Q., 2011. Expression of autophagy-related genes in the anterior silk gland of Bombyx mori during metamorphosis. Canadian Journal of Zoology, 89: 1019-1026

– Tettamanti G., Cao Y., Feng Q., Grimaldi A. and de Eguileor M., 2011. Autophagy in Lepidoptera: more than old wine in new bottle. Invertebrate Survival Journal, 8: 5-14 (Free full text)

– Li Q., Deng X., Yang W., Huang Z., Tettamanti G., Cao Y. and Feng Q., 2010. Autophagy, apoptosis and ecdysis-related gene expression in the silk gland of the silkworm (Bombyx mori) during metamorphosis. Canadian Journal of Zoology, 88: 1169-1178 (Abstract)

– Malagoli D., Abdalla F.C., Cao Y., Feng Q., Fujisaki K., Gregorc A., Matsuo T., Nezis I.P., Papassideri I.S., Silva-Zacarin E.C.M., Tettamanti G. and Umemiya-Shirafuji R., 2010. Autophagy and its physiological relevance in arthropods: current knowledge and perspectives. Autophagy, 6: 575-588 (Abstract)

– Tettamanti G. and Casartelli M., 2010. Lepidopteran midgut stem cells in culture: a new tool for cell biology and physiological studies. In -Pluripotent stem cells- (Eds. D.W. Rosales and Q.N. Mullen), pp. 173-184. Nova Science Publishers, New York (Abstract)

– Tettamanti G. and Malagoli D., 2008. In vitro methods to monitor autophagy in Lepidoptera. Methods in Enzymology, 451: 685-709 (Abstract)

– Tettamanti G., Salo E., Gonzalez-Estevez C., Felix D.A., Grimaldi A. and de Eguileor M., 2008. Autophagy in invertebrates: insights into development and body remodeling. Current Pharmaceutical Design, 14: 116-125 (Abstract)

– Tettamanti G., Malagoli D., Ottaviani E. and de Eguileor M, 2008. OIigomycin A and the IPLB-LdFB insect cell line: actin and mitochondrial responses. Cell Biology International, 32: 287-292 (Abstract)

– Klionsky D.J.,………Tettamanti G.,…………Deter R.L., 2008. Guidelines for the use and interpretation of assays for monitoring autophagy in higher Eukaryotes. Autophagy, 4: 151-175 (Abstract)

– Tettamanti G., Grimaldi A., Pennacchio F. and de Eguileor M., 2008. Toxoneuron nigriceps parasitization delays midgut replacement in fifth-instar Heliothis virescens larvae. Cell & Tissue Research, 332: 371-379 (Abstract)

– Tettamanti G., Grimaldi A., Pennacchio F. and de Eguileor M., 2007. Lepidopteran larval midgut during prepupal instar: digestion or self-digestion? Autophagy, 3: 630-631 (Abstract)

– Tettamanti G., Grimaldi A., Casartelli M., Ambrosetti E., Ponti B., Congiu T., Ferrarese R., Rivas-Pena M.L., Pennacchio F. and de Eguileor M., 2007. Programmed cell death and stem cell differentiation are responsible for midgut replacement in Heliothis virescens during prepupal instar. Cell & Tissue Research, 330: 345-359 (Abstract)

– Tettamanti G. Malagoli D., Marchesini E., Congiu T., de Eguileor M. and Ottaviani E., 2006. Oligomycin A induces autophagy in the IPLB-LdFB insect cell line. Cell & Tissue Research, 326: 179-186 (Abstract)

INSECT BIOTECHNOLOGY

INSECT BIOCONVERSION

– Tettamanti G., Bruno D., 2024. Black soldier fly larvae should be considered beyond their use as feedstuff. Journal of Insects as Food and Feed, 10: 1-7 (Full text)

– Ma C., Huang Z., Feng X., Memon F.U., Cui Y., Duan X., Zhu J., Tettamanti G., Hu W., Tian L., 2024. Selective breeding of cold-tolerant black soldier fly (Hermetia illucens) larvae: Gut microbial shifts and transcriptional patterns. Waste Management, 177: 252-265 (Full text)

– Vandeweyer D., Bruno D., Bonelli M., Freek I., Lievens B., Crauwels S., Casartelli M., Tettamanti G., De Smet J., 2023. Bacterial biota composition in gut regions of black soldier fly larvae reared on industrial residual streams: revealing community dynamics along its intestinal tract. Frontiers in Microbiology, 14: 1276187 (Full text)

– De Filippis F., Bonelli M., Bruno D., Sequino G., Montali A., Reguzzoni M., Pasolli E., Savy D., Cangemi S., Cozzolino V., Tettamanti G., Ercolini D., Casartelli M., Caccia S., 2023. Plastics shape the black soldier fly larvae gut microbiome and select for biodegrading functions. Microbiome, 11: 205 (Full text)

– Ferronato N., Paoli R., Romagnoli F., Tettamanti G., Bruno D., Torretta V., 2023. Environmental impact scenarios of organic fraction municipal solid waste treatment with Black Soldier Fly larvae based on a life cycle assessment. Environmental Science and Pollution Research (Full text)

– Lievens S., Vervoort E., Bruno D., van der Donck T., Tettamanti G., Sep J.W., Poma G., Covaci A., De Smet J. and van der Borght M., 2023. Ingestion and excretion dynamics of microplastics by black soldier fly larvae and correlation with mouth opening size. Scientific Reports, 13: 4341 (Full text)

– Bruno D., Montali A., Gariboldi M., Wronska A.K., Kaczmarek A., Mohamed A., Tian L., Casartelli M. and Tettamanti G., 2022. Morphofunctional characterization of hemocytes in black soldier fly larvae. Insect Science, 30: 912-932 (Full text) 

– Tettamanti G., Van Campenhout L, and Casartelli M., 2022. A hungry need for knowledge on the black soldier fly digestive system. Journal of Insects as Food and Feed, 8: 217-222 (Full text)  

– Ceccotti C., Bruno D., Tettamanti G., Branduardi P., Bertacchi S., Labra M., Rimoldi S. and Terova G, 2022. New value from food and industrial wastes – Bioaccumulation of omega-3 fatty acids from an oleaginous microbial biomass paired with a brewery by-product using black soldier fly (Hermetia illucens) larvae. Waste Management, 143: 95-104 (Abstract)

– Bruno D., Montali A., Mastore M., Brivio M.F., Mohamed A., Tian L., Grimaldi A., Casartelli M. and Tettamanti G., 2021. Insights into the immune response of the black soldier fly larvae to bacteria. Frontiers in Immunology, 12: 745160 (Abstract) 

– Saviane A., Tassoni L., Naviglio D., Lupi D., Savoldelli S., Bianchi G., Cortellino G., Bondioli P., Folegatti L., Casaratelli M., Orlandi V.T., Tettamanti G., and Cappellozza S., 2021. Mechanical processing of Hermetia illucens larvae and Bombyx mori pupae produces oils with antimicrobial activity. Animals, 11: 783 (Full text)

– Bruno D., Bonacci T., Reguzzoni M., Casartelli M., Grimaldi A., Tettamanti G. and Brandmayr P., 2020. An in-depth description of the head morphology and mouthparts in larvae of the black soldier fly, Hermetia illucens. Arthropod Structure & Development, 58: 100969

– Bonelli M., Bruno D., Brilli M., Gianfranceschi N., Tian L., Tettamanti G., Caccia S. and Casartelli M., 2020. Black soldier fly larvae adapt to different food substrates through morphological and functional responses of the midgut. International Journal of Molecular Sciences, 21: 4955 (Full text)

– Gold M., Egger J, Scheidegger A., Zurbrügg C., Bruno D., Bonelli M., Tettamanti G., Casartelli M., Schmitt E., Kerkaert B., De Smet J., Van Campenhout L. and Mathys A., 2020. Estimating black soldier fly larvae biowaste conversion performance by simulation of midgut digestion. Waste Management, 112: 40-51 (Abstract)

– Bruno D., Bonelli M., Cadamuro A.G., Reguzzoni M., Grimaldi A., Casartelli M. and Tettamanti G., 2019. The digestive system of the adult Hermetia illucens (Diptera: Stratiomyidae): morphological features and functional properties. Cell & Tissue Research, 378: 221-238 (Abstract)

– Bonelli M., Bruno D., Caccia S., Sgambetterra G., Cappellozza S., Jucker C., Tettamanti G. and Casartelli M., 2019. Structural and functional characterization of Hermetia illucens larval midgut. Frontiers in Physiology, 10: 204 (Free full text)

– Bruno D., Bonelli M., De Filippis F., Di Lelio I., Tettamanti G., Casartelli M., Ercolini D. and Caccia S., 2019. The intestinal microbiota of Hermetia illucens larvae is affected by diet and shows a diverse composition in the different midgut regions. Applied & Environmental Microbiology, 85: e01864-18 (Free full text)

– Cappellozza S., Leonardi M.G., Savoldelli S., Carminati D., Rizzolo A., Cortellino G., Terova G., Moretto E., Badaile A., Concheri G., Saviane A., Bruno D., Bonelli M., Caccia S., Casartelli M. and Tettamanti G., 2019. A first attempt to produce proteins from insects by means of a circular economy. Animals, 9: E278 (Free full text)

– Pimentel A.C., Montali A., Bruno D. and Tettamanti G., 2017. Metabolic adjustment of the larval fat body in Hermetia illucens to dietary conditions. Journal of Asia-Pacific Entomology, 20: 1307

CONTROL OF PEST INSECTS

– Di Lelio I., Giobbe F., Magoga G., Brunetti M., Bruno D., Becchimanzi A., De Luca M.G., Sinno M., Barra E., Bonelli M., Frusciante S., Gianfranco D., Digilio M.C., Sheridan W.L., Tettamanti G., Rao R., Lorito M., Casartelli M., Montagna M. and Pennacchio F., 2023. A soil fungus confers plant resistance against a phytophagous insect by disrupting the symbiotic role of its gut microbiota. Proceedings of the National Academy of Sciences of USA, 120: e2216922120 (Full text)

– Eleftherianos I., Zhang W., Heryanto C., Mohamed A., Contreras G., Tettamanti G., Wink M. and Bassal T., 2021. Diversity of insect antimicrobial peptides and proteins – A functional perspective: a review. International Journal of Biological Macromolecules, 191: 277-287 (Abstract) 

– Eleftherianos I., Heryanto C., Bassal T., Zhang W., Tettamanti G. and Mohamed A., 2021. Haemocyte-mediated immunity in insects: cells, processes, and associated components in the fight against pathogens and parasites. Immunology, 164: 401-432 (Abstract) 

– Zhang, W., Tettamanti G., Bassal T., Heryanto C., Eleftherianos I. and Mohamed A., 2021. Regulators and signalling in insect antimicrobial innate immunity: functional molecules and cellular pathways. Cellular Signalling, 83:110003 (Abstract) 

– Berini F., Casartelli M., Montali A., Reguzzoni M., Tettamanti G. and Marinelli F., 2019. Metagenome-sourced microbial chitinases as potential insecticide proteins. Frontiers in Microbiology, 10: 1358 (Free full text)

– Berini F., Katz C., Gruzdev N., Casartelli M., Tettamanti G. and Marinelli F., 2018. Microbial and viral chitinases: attractive biocontrol agents for integrated pest management. Biotechnology Advances, 36: 818-838

– Bruno D., Grossi G., Salvia R., Scala A., Farina D., Grimaldi A., Zhou J.J., Bufo S.A., Vogel H, Grosse-Wilde E., Hansson B.S. and Falabella P., 2018. Sensilla morphology and complex expression pattern of odorant binding proteins in the vetch aphid Megoura viciae (Hemiptera: Aphididae). Frontiers in Physiology, 9:777

– Caccia S., Di Lelio I., La Storia A., Marinelli A., Varricchio P., Franzetti E., Banyuls N., Tettamanti G., Casartelli M., Giordana B., Ferré J., Gigliotti S., Ercolini D. and Pennacchio F., 2016. Midgut microbiota and host immunocompetence underlie Bacillus thuringiensis killing mechanism. Proceedings of the National Academy of Sciences of USA, 113: 9486-9491 (Abstract)

– Berini F., Caccia S., Franzetti E., Congiu T., Marinelli F., Casartelli M. and Tettamanti G., 2016. Effects of Trichoderma viride chitinases on the peritrophic matrix of Lepidoptera. Pest Management Science, 72: 980-989 (Abstract)

– De Biasio F., Riviello L., Bruno D., Grimaldi A., Congiu T., Sun Y.F. and Falabella P., 2015. Expression pattern analysis of odorant-binding proteins in the pea aphid Acyrthosiphon pisum. Insect Science 22: 220-234 (Abstract)

– Pascale M., Laurino S., Vogel H., Grimaldi A., Monnè M., Riviello L., Tettamanti G. and Falabella P., 2014. The Lepidopteran endoribonuclease-U domain protein P102 displays dramatically reduced enzymatic activity and forms functional amyloids. Develeopmental & Comparative Immunology 47: 129-139

– Grimaldi A., Tettamanti G., Congiu T., Girardello R., Malagoli D., Falabella P., Valvassori R., Ottaviani E. and de Eguileor M., 2012. The main actors involved in parasitization of Heliothis virescens larva. Cell & Tissue Research, 350: 491-502 (Abstract)

– Falabella P., Riviello L., Pascale M., Di Lelio I., Tettamanti G., Grimaldi A., Iannone C., Monti M., Pucci P., Tamburro A.M., de Eguileor M., Gigliotti S. and Pennacchio F., 2012. Functional amyloids in insect immune response. Insect Biochemistry & Molecular Biology, 42: 203-211 (Abstract)

– Falabella P., Riviello L., De Stradis M.L., Stigliano C., Varricchio P., Grimaldi A., de Eguileor M., Graziani F., Gigliotti S. and Pennacchio F., 2009. Aphidius ervi teratocytes release an extracellular enolase. Insect Biochemistry & Molecular Biology, 39: 801-813 (Abstract)

– Caccia S., Casartelli M., Grimaldi A., Losa E., de Eguileor M., Pennacchio F. and Giordana B., 2007. Unexpected similarity of intestinal sugar absorption by SGLT1 and apical GLUT2 in an insect (Aphidius ervi, Hymenoptera) and mammals. American Journal of Physiology -Regulatory, integrative and comparative physiology-, 292: R2284-2291 (Abstract)

– Falabella P., Varricchio P., Provost B., Espagne E., Ferrarese R., Grimaldi A., de Eguileor M., Fimiani G., Ursini M.V., Malva C., Drezen J.M. and Pennacchio F., 2007. Characterization of the IkappaB-like gene family in polydnaviruses associated with wasps belonging to different Braconid subfamilies. The Journal of General Virology, 88: 92-104 (Abstract)

– Grimaldi A., Caccia S., Congiu T., Ferrarese R., Tettamanti G., Rivas-Pena M., Perletti G., Valvassori R., Valvassori R., Giordana B., Falabella P., Pennacchio F. and de Eguileor M., 2006. Structure and function of the extraembryonic membrane persisting around the larvae of the parasitoid Toxoneuron nigriceps. Journal of Insect Physiology, 52: 870-880 (Abstract)

– Caccia S., Leonardi M.G., Casartelli M., Grimaldi A., de Eguileor M., Pennacchio F. and Giordana B., 2005. Nutrient absorption by Aphidius ervi larvae. Journal of Insect Physiology, 51:1183-1192 (Abstract)

– Ferrarese R., Brivio M., Congiu T., Falabella P., Grimaldi A., Mastore M., Perletti G., Pennacchio F., Sciacca L., Tettamanti G., Valvassori R. and de Eguileor M., 2005. Early suppression of immune response in Heliothis virescens larvae by the endophagous parasitoid Toxoneuron nigriceps. Invertebrate Survival Journal, 2: 60-68 (Free full text)

– Rao R., Fiandra L., Giordana B., de Eguileor M., Congiu T., Burlini N., Arciello S., Corrado G. and Pennacchio F., 2004. AcMNPV ChiA protein disrupts the peritrophic membrane and alters midgut physiology of Bombyx mori larvae. Insect Biochemistry & Molecular Biology, 34: 1205-1213. (Abstract)

– Giordana B., Milani A., Grimaldi A., Farneti R., Casartelli M., Ambrosecchio M.R., Digilio M.C., Leonardi M.G., de Eguileor M. and Pennacchio F., 2003. Absorption of sugars and amino acids by the epidermis of Aphidius ervi larvae. Journal of Insect Physiology, 49: 1115-1124 (Abstract)

– de Eguileor M., Grimaldi A., Tettamanti G., Valvassori R., Leonardi M.G., Giordana B., Tremblay E., Digilio M.C. and Pennacchio F., 2001. Larval anatomy and structure of absorbing epithelia in the aphid parasitoid Aphidius ervi Haliday (Hymenoptera, Braconidae). Arthropod Structure & Development, 30: 27-37

SILKWORM

– Cappellozza S., Casartelli M., Sandrelli F., Saviane A., Tettamanti G., 2022. Silkworm and silk: traditional and innovative applications. Insects, 13: 1016 (Full text)

– Montali A., Berini F, Saviane A., Cappellozza S., Marinelli F., and Tettamanti G., 2020. A Bombyx mori infection model for screening antibiotics against Staphylococcus epidermidis. Insects, 13: 748 (Abstract) 

– Montali A., Berini F, Brivio M., Mastore M., Saviane A., Cappellozza S., Marinelli F. and Tettamanti G., 2020. A silkworm infection model for in vivo study of glycopeptide antibiotics. Antibiotics, 9: 300 (Abstract)

– Santorum M., Brancalhão R.M.C., Guimarães A.T.B., Padovani C.R., Tettamanti G. and Dos Santos D.C., 2019. Negative impact of Novaluron on the non target insect Bombyx mori (Lepidoptera: Bombycidae). Environmental Pollution, 249: 82-90 (Abstract)

– Romoli O., Mukherjee S., Mohid S.A., Dutta A., Montali A., Franzolin E., Brady D., Zito F., Bergantino E., Rampazzo C., Tettamanti G., Bhunia A. and Sandrelli F., 2019. A single amino acid variation in the silkworm cecropin B enhances the antimicrobial activity against Pseudomonas aeruginosa. ACS Infectious Diseases, 5: 1200-1213 (Abstract)

– Saviane A., Romoli O., Bozzato A., Freddi G., Cappeletti C., Rosini E., Cappellozza S., Tettamanti G. and Sandrelli F., 2018. Intrinsic antimicrobial properties of silk spun by genetically modified silkworm strains. Transgenic Research, 27: 87

– Romoli O., Saviane A., Bozzato A., D’Antona P., Tettamanti G., Squartini A., Cappellozza S. and Sandrelli F., 2017. Differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin. Scientific Reports,7: 1048

– Wöltje M., Böbel M., Rheinnecker M., Tettamanti G., Franzetti E., Saviane A. and Cappellozza S., 2014. Transgenic protein production in silkworm silk glands requires cathepsin and chitinase of Autographa californica multicapsid nucleopolyhedrovirus. Applied Microbiology & Biotechnology, 98: 4571-4580 (Abstract)

– Cappellozza S., Saviane A., Tettamanti G., Squadrin M., Vendramin E., Paolucci P., Franzetti E. and Squartini A., 2011. Identification of Enterococcus mundtii as a pathogenic agent involved in the flacherie disease in Bombyx mori L. larvae reared on artificial diet. Journal of Invertebrate Pathology, 106: 386-393 (Abstract)

IMMUNITY, WOUND HEALING AND ANGIOGENESIS IN LEECHES

– Baranzini N., Pulze L., Tettamanti G., Acquati F. and Grimaldi A., 2021. HvRNASET2 regulate connective tissue and collagen I remodeling during wound healing process. Frontiers in Physiology, 12: 632506 (Full text)

– Baranzini N., De Vito A., Orlandi V.T., Reguzzoni M., Monti L., de Eguileor M., Rosini E., Pollegioni L, Tettamanti G., Acquati F. and Grimaldi A., 2020. Antimicrobial Role of RNASET2 protein during innate immune response in the medicinal leech Hirudo verbana. Frontiers in Immunology, 11: 370 (Abstract)

– Baranzini N., Weiss-Gayet M., Chazaud B., Monti L., de Eguileor M., Tettamanti G., Acquati F. and Grimaldi A., 2020. Recombinant HvRNASET2 protein induces a marked connective tissue remodelling in the invertebrate model Hirudo verbana. Cell & Tissue Research, 380: 565-579 (Abstract)

– Baranzini N., Monti L., Vanotti M., Orlandi V.T., Bolognese F., Scaldaferri D., Girardello R., Tettamanti G., de Eguileor M., Vizioli J., Taramelli R., Acquati F. and Grimaldi A., 2018. AIF-1 and RNASET2 play complementary roles in the innate immune response of medicinal leech. Journal of Innate Immunity, 26: 1-18

– Pulze L., Baranzini N., Girardello R., Grimaldi A., Ibba-Manneschi L., Ottaviani E., Reguzzoni M., Tettamanti G. and de Eguileor M., 2017. A new cellular type in invertebrates: first evidence of telocytes in leech Hirudo medicinalis. Scientific Reports, 7: 13580 (Abstract)

– Baranzini N., Pedrini E., Girardello R., Tettamanti G., de Eguileor M., Taramelli R., Acquati F. and Grimaldi A., 2017. Human recombinant RNASET2-induced inflammatory response and connective tissue remodeling in the medicinal leech. Cell & Tissue Research, 368: 337-351 (Abstract)

– Grimaldi A., 2016. Origin and fate of hematopoietic stem precursor cells in the leech Hirudo medicinalis. Invertebrate Survival Journal 13: 257-268 (Free full text)

– Schorn T., Drago F., Tettamanti G., Valvassori R., de Eguileor M., Vizioli J. and Grimaldi A., 2015. Homolog of allograft inflammatory factor-1 induces macrophage migration during innate immune response in leech. Cell & Tissue Research, 359: 853-864 (Abstract)

– Schorn T., Drago F., de Eguileor M., Valvassori R., Vizioli J., Tettamanti G. and Grimaldi A., 2015. The Allograft Inflammatory Factor-1 (AIF-1) homologous in Hirudo medicinalis (medicinal leech) is involved in immune response during wound healing and graft rejection processes. Invertebrate Survival Journal, 12: 129-141 (Full text)

– Girardello R., Tasselli S., Baranzini N., Valvassori R., de Eguileor M. and Grimaldi A., 2015. Effects of carbon nanotube environmental dispersion on an aquatic invertebrate, Hirudo medicinalis. PLoS ONE 10: e0144361 (Abstract)

– Girardello R., Drago F., de Eguileor M., Valvassori R., Vizioli J., Tettamanti G. and Grimaldi A., 2015. Cytokine impregnated biomatrix: a new tool to study multi-wall carbon nanotubes effects on invertebrate immune cells. Journal of Nanomedicine and Nanotechnology, 6: 5 (Free full text)

– Grimaldi A., Ferrarese R., Tettamanti G., Valvassori R. and de Eguileor M., 2013. Ras activation in Hirudo medicinalis angiogenic proocess. Invertebrate Survival Journal, 10: 7-14 (Full text)

– Grimaldi A., Banfi S., Vizioli J., Tettamanti G., Douglas M.N. and de Eguileor M., 2011. Cytokine loaded biopolymers as a novel strategy to study stem cells during wound healing processes.  Macromolecular Bioscience 11: 1008-1019 

– Grimaldi A., Banfi S., Gerosa L., Tettamanti G., Noonan D.M., Valvassori R. and de Eguileor M., 2009. Identification, isolation and expansion of myoendothelial cells involved in leech muscle regeneration. PLoS One, 4: e7652 (Abstract)

– Grimaldi A., Bianchi C., Greco G., Tettamanti G., Noonan D.M., Valvassori R. and de Eguileor M., 2008. In vivo isolation and characterization of stem cells with diverse phenotypes using growth factor impregnated biomatrices. Plos ONE, 3: e1910 (Abstract)

– Tettamanti G., Malagoli D., Benelli R., Albini A., Grimaldi A., Perletti G., Noonan D.M., de Eguileor M. and Ottaviani E., 2006. Growth factors and chemokines: a comparative functional approach between invertebrates and vertebrates. Current Medicinal Chemistry, 13: 2737-2750 (Abstract)

– Grimaldi A., Tettamanti G., Perletti G., Valvassori R. and de Eguileor M., 2006. Hematopoietic cell formation in leech wound healing. Current Pharmaceutical Design, 12: 3033-3041 (Abstract)

– Tettamanti G., Grimaldi A., Congiu T., Perletti G., Raspanti M., Valvassori R. and de Eguileor M., 2005. Collagen reorganization in leech wound healing. Biology of the Cell , 97: 557-568 (Abstract)

– Tettamanti G., Grimaldi A., Rinaldi L., Arnaboldi F., Congiu T., Valvassori R. and de Eguileor M., 2004. The multifunctional role of fibroblasts during wound healing in Hirudo medicinalis (Annelida, Hirudinea). Biology of the Cell, 96: 443-455 (Abstract)

– Grimaldi A., Tettamanti G., Rinaldi L., Valvassori R. and de Eguileor M., 2004. Role of cathepsin B in leech wound healing. Invertebrate Survival Journal, 1: 36-48 (Free full text)

– de Eguileor M., Tettamanti G., Grimaldi A., Perletti G., Congiu T., Rinaldi L. and Valvassori R., 2004. Hirudo medicinalis: avascular tissue for clear-cut angiogenesis studies? Current Pharmaceutical Design, 10: 1979-1988 (Abstract)

– Tettamanti G., Grimaldi A., Valvassori R., Rinaldi L. and de Eguileor M., 2003. Vascular Endothelial Growth Factor is involved in neoangiogenesis in Hirudo medicinalis (Annelida, Hirudinea). Cytokine, 22: 168-179 (Abstract)

– Tettamanti G., Grimaldi A., Ferrarese R., Palazzi M., Perletti G., Valvassori R., Cooper E.L., Lanzavecchia G. and de Eguileor M., 2003. Leech responses to tissue transplantation. Tissue & Cell, 35: 199-212 (Abstract)

– de Eguileor M., Grimaldi A., Tettamanti G., Valvassori R. and Cooper E.L., 2003. State of art for the immune system in leeches, in “The new panorama of animal evolution. Proc 18th Congr. Zoology” pp. 139-145, Edited by: A. Legakis, S. Sfenthourakis, R. Polymeni, and M. Thessalou-Legaki, Pensoft publishers, Sofia & Moscow

– Perletti G., Marras E., Dondi D., Grimaldi A., Tettamanti G., Valvassori R. and de Eguileor M., 2003. Assessment of the biological activity of an improved naked-DNA vector for angiogenesis gene therapy on a non-mammalian model. International Journal of  Molecular Medicine, 11: 691-696 (Abstract)

– de Eguileor M., Tettamanti G., Grimaldi A., Congiu T., Ferrarese R., Perletti G., Valvassori R., Cooper E.L. and Lanzavecchia G., 2003. Leeches: immune response, angiogenesis and biomedical applications. Current Pharmaceutical Design, 9: 133-147 (Abstract)

– de Eguileor M., Tettamanti G., Grimaldi A., Ferrarese R., Perletti G., Valvassori R., Cooper E.L. and Lanzavecchia G., 2002. Leech immune responses: contributions and biomedical applications, in “A new model for analyzing antimicrobial peptides with biomedical applications” Vol. 343 NATO Science Series: Life and Behavioural Sciences, Edited by: E. Cooper and M. Biley, IOS Press, The Netherlands

– de Eguileor M., Grimaldi A., Tettamanti G., Ferrarese R., Congiu T., Protasoni M., Perletti G., Valvassori R. and Lanzavecchia G., 2001. Hirudo medicinalis: a new model system for testing activators and inhibitors of angiogenesis. Angiogenesis, 4: 299-312 (Abstract)

– de Eguileor M., Grimaldi A., Tettamanti G., Congiu T., Protasoni M., Reguzzoni M., Valvassori R. and Lanzavecchia G., 2001. Ultrastructure and functional versatility of hyrudinean botryoidal tissue. Tissue & Cell, 33: 332-341 (Abstract)

– de Eguileor M., Grimaldi A., Tettamanti G., Boselli A., Valvassori R., Cooper E.L. and Lanzavecchia G., 2000. Lipopolysaccharide-dependent induction of leech leukocytes that cross- react with vertebrate cellular differentiation markers. Tissue & Cell, 32: 437-445 (Abstract)

– de Eguileor M., Grimaldi A., Tettamanti G., Valvassori R., Cooper E.L. and Lanzavecchia G., 2000. Different types of response against foreign antigens by leech leukocytes. Tissue & Cell, 32: 40-48  (Abstract)

– de Eguileor M., Tettamanti G., Grimaldi A., Boselli A., Scarì G., Valvassori R., Cooper E.L. and Lanzavecchia G., 1999. Histopathological changes after induced injury in leeches. Journal of Invertebrate Pathology, 74: 14-28 (Abstract)

MUSCLE DEVELOPMENT (INVERTEBRATES AND VERTEBRATES)

– Banfi S., Monti L., Acquati F., Tettamanti G., de Eguileor M. and Grimaldi A., 2012. Muscle development and differentiation in the urodele Ambystoma mexicanum. Development Growth & Differentiation, 54: 489-502 (Abstract)

– Tettamanti G. and Grimaldi A., 2010. Current perspectives on muscle regeneration. Current Pharmaceutical Design, 16: 904-905 (Abstract)

– Grimaldi A., Banfi S., Bianchi C., Greco G., Tettamanti G., Noonan D.M., Valvassori R. and de Eguileor M., 2010. A novel invertebrate model for studying muscle regeneration and diseases. Current Pharmaceutical Design, 16: 968-977 (Abstract)

– Grimaldi A., Tettamanti G., Acquati F., Bossi E., Guidali M.L., Banfi S., Monti L., Valvassori R. and de Eguileor M., 2008. A hedgehog homolog is involved in muscle formation and organization of Sepia officinalis (Mollusca) mantle. Developmental Dynamics, 237: 659-671 (Abstract)

– Hammond C.L., Hinits Y., Osborn D.P.S., Minchin J., Tettamanti G. and Hughes S.M., 2007. Signals and myogenic regulatory factors restrict pax 3/7 expression to dermomyotome-like tissues in zebrafish. Developmental Biology, 302: 504-521 (Abstract)

– Grimaldi A., Tettamanti G., Guidali M.L., Brivio M.F., Valvassori R. and de Eguileor M., 2007. A Hedgehog-like signal is involved in slow muscle differentiation in Sepia officinalis (Mollusca). Invertebrate Survival Journal, 4: 1-9 (Full text)

– Grimaldi A., Tettamanti G., Martin B.L., Gaffield W., Pownall M.E. and Hughes S.M., 2004. Hedgehog regulation of superficial slow muscles fibres in Xenopus and the evolution of tetrapod trunk myogenesis. Development, 131: 3249-3262 (Abstract)

– Grimaldi A., Tettamanti G., Brivio M. F., Valvassori R. and de Eguileor M., 2004. Differentiation of slow and fast fibers in tentacles of Sepia officinalis (Mollusca). Development Growth & Differentiation, 46: 181-193 (Abstract)

– Grimaldi A., Tettamanti G., Rinaldi L., Brivio M. F., Castellani D. and de Eguileor M., 2004. Muscle differentiation in tentacle of Sepia officinalis (Mollusca) is regulated by muscle regulatory factors (MRFs) related proteins. Development Growth & Differentiation, 46: 83-96 (Abstract)

– de Eguileor M., Grimaldi A., Boselli A., Tettamanti G., Lurati S., Valvassori R. and Lanzavecchia G., 1999. Possible roles of extracellular matrix and cytoskeleton in leech body wall muscle. Journal of Microscopy, 196: 6-18 (Abstract)

– de Eguileor M., Grimaldi A., Lanzavecchia G., Tettamanti G. and Valvassori R., 1998. Dimensional and numerical growth of helical fibers in leeches: an unusual pattern. The Journal of Experimental Zoology, 281: 171-187

MISCELLANEOUS PAPERS

– Favaro R., Garrido P.M., Bruno D., Braglia C., Alberoni D., Baffoni L., Tettamanti G., Porrini M.P., Di Gioia D., Angeli S., 2023. Combined effect of a neonicotinoid insecticide and a fungicide on honeybee gut epithelium and microbiota, adult survival, colony strength and foraging preferences. Science of The Total Environment, 905: 167277 (Full text)

– Pulze L., Baranzini N., Congiu T., Acquati F., Grimaldi A., 2022. Spatio-temporal changes of extracellular matrix (ECM)
stiffness in the development of the leech Hirudo verbana. International Journal of Molecular Sciences, 23: 15953 (Full text)

– Piroddi N., Pesce P., Scellini B., Manzini S., Ganzetti G.S., Badi I., Menegollo M., Cora V., Tiso S., Cinquetti R., Monti L., Chiesa G., Bleyl S.B., Busnelli M., Dellera F., Bruno D., Caicci F., Grimaldi A., Taramelli R., Manni L., Sacerdoti D., Tesi C., Poggesi C., Ausoni S., Acquati F. and Campione M., 2020. Myocardial overexpression of ANKRD1 causes sinus venosus defects and progressive diastolic dysfunction. Cardiovascular Research, 116: 1458-1472 (Full text)

– Russo R, Varano G.P., Adornetto A., Nazio F., Tettamanti G., Girardello R., Cianfanelli V., Cavaliere F., Morrone L.A., Corasaniti M.T., Cecconi F., Bagetta G. and Nucci C., 2018. Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival. Cell Death & Disease, 9: 981-998 (Abstract)

– Manzoni E., Pennarossa G., de Eguileor M., Tettamanti G., Gandolfi F. and Brevini T., 2016. 5-azacytidine affects TET2 and histone transcription and reshapes morphology of human skin fibroblasts. Scientific Reports, 6: 37017 (Abstract)

– Pulze L., Bassani B., Gini E., D’Antona P., Grimaldi A., Luini A., Marino F., Noonan D., Tettamanti G., Valvassori R. and de Eguileor M., 2016. Net amyloidogenic backbone in human activated neutrophils. Clinical & Experimental Immunology, 183: 469-479 (Abstract)

– Grossi G., Grimaldi A., Cardone R.A., Monné M., Reshkin S.J., Girardello R., Greco M.R., Coviello E., Laurino S. and Falabella P., 2016. Extracellular matrix degradation via Enolase/Plasminogen interaction: evidence for a mechanism conserved in Metazoa. Biology of the Cell 108 :161-178 (Abstract)

– Calisi A,. Grimaldi A., Leomanni A., Lionetto M.G., Dondero F. and Schettino T., 2016. Multibiomarker response in the earthworm Eisenia fetida as tool for assessing multi-walled carbon nanotube ecotoxicity. Ecotoxicology 25: 677-687 (Abstract)

– Pennarossa G., Maffei S., Tettamanti G., Congiu T., de Eguileor M., Gandolfi F. and Brevini T., 2015. Intracellular bridges are essential for human parthenogenetic cell survival. Mechanisms of Development, 136: 30-39 (Abstract)

– Albini A., Pagani A., Pulze L., Bruno A., Principi E., Congiu T., Gini E., Grimaldi A., Bassani B., De Flora S., de Eguileor M. and Noonan D.M., 2015. Environmental impact of multi-wall carbon nanotubes in a novel model of exposure: systemic distribution, macrophage accumulation, and amyloid deposition. International Journal of Nanomedicine, 10: 6133–6145 (Abstract)

– Brevini T.A., Pennarossa G., Rahman M.M., Antonini A., Ragni G., de Eguileor M., Tettamanti G. and Gandolfi F., 2014. Morphological and molecular changes of human granulosa cells exposed to 5-azacytidine and addressed toward muscular differentiation. Stem Cell Reviews & Reports, 10: 633-642 (Abstract)

– Orlandi V., Caruso E., Tettamanti G., Banfi S. and Barbieri P., 2013. Photoinduced antibacterial activity of two dicationic 5,15-diarylporphyrins. Journal of photochemistry & photobiology. B, Biology, 127C: 123-132 (Abstract)

– Brevini T.A., Pennarossa G., Maffei S., Tettamanti G., Vanelli A., Isaac S., Eden A., Ledda S., de Eguileor M. and Gandolfi F., 2012. Centrosome amplification and chromosomal instability in human and animal parthenogenetic cell lines. Stem Cell Reviews & Reports, 8: 1076-1087 (Abstract)

– Acquati F., Bertilaccio S., Grimaldi A., Monti L., Cinquetti R., Bonetti P., et al, 2011. Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase. Proceedings of the National Academy of Sciences of USA, 108: 1104-1109 (Abstract)

– Brevini T.A., Pennarossa G., de Eguileor M., Tettamanti G., Ragni G., Paffoni A. and Gandolfi F., 2010. Parthenogenetic cell lines: an unstable equilibrium between pluripotency and malignant transformation. Current Pharmaceutical Biotechnology, 12: 206-212 (Abstract)

– Tettamanti G., Cattaneo A.G., Gornati R., de Eguileor M., Bernardini G. and Binelli G., 2010. Phylogenesis of Brain Derived Neurotrophic Factor (BDNF) in Vertebrates. Gene, 450: 85-93 (Abstract)

– Brevini T.A., Pennarossa G., Antonini S., Paffoni A., Tettamanti G., Montemurro T., Radaelli E., Lazzari L., Rebulla P., Scanziani E., de Eguileor M., Benvenisty N., Ragni G. and Gandolfi F., 2009. Cell lines derived from human parthenogenetic embryos can display aberrant centriole distribution and altered expression levels of mitotic spindle check-point transcripts. Stem Cell Reviews & Reports, 5: 340-352 (Abstract)

– Brizzola S., de Eguileor M., Brevini T., Grimaldi A., Congiu T., Neuenschwander P. and Acocella F., 2009. Morphologic features of biocompatibility and neoangiogenesis onto a biodegradable tracheal prosthesis in an animal model. Interactive Cardiovascular & Thoracic Surgery, 8: 610-614 (Abstract)

– Pelucchi B., Grimaldi A. and Moriondo A., 2008. Vertebrate rod photoreceptors express both BK and IK calcium-activated potassium channels, but only BK channels are involved in receptor potential regulation. Journal of Neuroscience Research (Abstract)

– Cillo F., de Eguileor M., Gandolfi F. and Brevini T.A., 2007. Aroclor-1254 affects mRNA polyadenylation, translational activation, cell morphology, and DNA integrity of rat primary prostate cells. Endocrine-Related Cancer 14: 257-266 (Abstract)

– Magri V., Trinchieri A., Montanari E., Del Nero A., Mangiarotti B., Zirpoli P., de Eguileor M., Marras E., Ceriani I., Vral A. and Perletti G., 2007. Reduction of PSA values by combination pharmacological therapy in patients with chronic prostatitis: implications for prostate cancer detection. Archivio Italiano di Urologia Andrologia 79: 84-92 (Abstract)

– Moriondo A., Grimaldi A., Sciacca L., Guidali M.L., Marcozzi C. and Negrini D., 2007. Regional recruitment of rat diaphragmatic lymphatics in response to increased pleural or peritoneal fluid load. Journal of Physiology, 579: 835-847 (Abstract)

– Grimaldi A., Moriondo A., Sciacca L., Guidali M.L., Tettamanti G. and Negrini D., 2006. Functional arrangement of the rat diaphragmatic initial lymphatic network. American Journal of Physiology – Heart. Circ. Physiol., 291: H876-885 (Abstract)

– Rinaldi L., Basso P., Tettamanti G., Grimaldi A., Terova G., Saroglia M. and de Eguileor M., 2005. Oxigen availability causes morphological changes and a different VEGF/Flk-1/HIF-2 expression pattern in sea bass (Dicentrarchus labrax) gills. The Italian Journal of Zoology , 72: 103-111

– Perletti G., Marras E., Dondi D., Osti D., Congiu T., Ferrarese R., de Eguileor M. and Tashjian A.H. Jr., 2005. p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells. International Journal of Cancer, 113: 42-53 (Abstract)

– Tettamanti G., Grimaldi A., Ferrarese R., Rinaldi L., Bortolotto A., Di Guardo G. and de Eguileor M., 2004. A comparative study of sporta perimedullaris muscolosa in the renicule of six species of cetaceans. The Italian Journal of Zoology, 71: 115-121 (Errata 71: 271-273)

– Perletti G., Osti D., Marras E., Tettamanti G. and de Eguileor M., 2004. Generation of VSV-G pseudotyped lentiviral particles in 293T cells. Journal of Cellular & Molecular Medicine, 8: 142-143 (Free full text)

– Perletti G., Marras E., Osti D., Felici L., Zaro S. and de Eguileor M., 2004. PKC delta requires p53 for suppression of the transformed phenotype in human colon cancer cells. Journal of Cellular & Molecular Medicine, 8: 563-569 (Abstract)

– Rinaldi L., Grimaldi A., Tettamanti G., Terova G., Saroglia M., Valvassori R. and de Eguileor M., 2004. I livelli di ossigeno influenzano l’organizzazione strutturale delle branchie in Dicentrarchus labrax. Biologia Marina Mediterranea, 10: 1133-1135

– Protasoni M., de Eguileor M., Congiu T., Grimaldi A. and Reguzzoni M. The extracellular matrix of the cuticle of Gordius panigettensis (Gordioiidae, Nematomorpha): observations by TEM, SEM and AFM. Tissue & Cell, 35: 306-311 (Abstract)

– de Eguileor M., Giordana B., Leonardi M. G., Grimaldi A., Tettamanti G., Fiandra L., Valvassori R. and Lanzavecchia G., 2000. Integumental amino acid uptake in a carnivorous predator mollusc (Sepia officinalis, Cephalopoda). Tissue & Cell, 32: 389-399 (Abstract)

– Brivio M.F., de Eguileor M., Grimaldi A., Vigetti D., Valvassori R. and Lanzavecchia G., 2000. Structural and biochemical analysis of the parasite Gordius villoti (Nematomorpha, Gordiacea) cuticle. Tissue & Cell, 32: 366-376 (Abstract)