Gruppo di Ricerca in Immunologia e Patologia Generale

L’organizzazione del gruppo è la seguente:

Componenti strutturati:  Douglas M. Noonan (Professore Associato),  Lorenzo Mortara (Ricercatore).

Componenti non strutturati al momento attuale:  Teresa Rossi (Studente di PhD).

Progetti in corso:

  • Studio delle interazioni fra tumore ed ospite, cross-talk fra il microambiente tumorale e il sistema immunitario.
  • Caratterizzazione e analisi funzionale delle cellule NK (natural killer) infiltranti il tumore nel contesto di differenti tipi di neoplasie umane, quali il NSCLC, il tumore colorettale, i carcinomi mammari, le effusioni pleuriche maligne e il mieloma multiplo.
  • Studio della polarizzazione, indotta da neoplasia, delle cellule NK pro-angiogeniche nei cancri umani.
  • Valutazione delle specie sieriche di microRNA, specifiche di tumori, come marcatori diagnostici precoci del carcinoma del polmone.
  • Studio dell’effetto dei nanotubi di carbonio su sistemi biologici.

Studi in Cooperazione con gruppi Interni, Nazionali ed Internazionali.

Collaborazioni interne

  • Dipartimento di Medicina e Chirurgia

Collaborazioni in ambito Nazionale:

Collaborazioni in ambito Internazionale:

  • AG Klinische Biochemie / Proteolyse, Institut für Laboratoriumsmedizin, Klinikum der Universität München (LMU) München, Germany
  • Angiogenesis Foundation, Boston MA, USA

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Pubblicazioni

Anno 2017

  1. Albini A, Bassani B, Baci D, Dallaglio K, Gallazzi M, Corradino P, Bruno A, Noonan DM. Nutraceuticals and “repurposed” drugs of phytochemical origin in prevention and interception of chronic degenerative disease and cancer. Curr Med Chem. 2017 Sep 20
  2. Balza E, Zanellato S, Poggi A, Reverberi D, Rubartelli A, Mortara L. The therapeutic T-cell response induced by tumor delivery of TNF and melphalan is dependent on early triggering of natural killer and dendritic cells. Eur J Immunol. 2017 Apr;47(4):743-753.
  3. Cristoni S, Dusi G, Brambilla P, Albini A, Conti M, Brambilla M, Bruno A, Di Gaudio F, Ferlin L, Tazzari V, Mengozzi S, Barera S, Sialer C, Trenti T, Cantu M, Rossi Bernardi L, Noonan DM. SANIST: optimization of a technology for compound identification based on the European Union directive with applications in forensic, pharmaceutical and food analyses. J Mass Spectrom. 2017; 52:16-21.
  4. Focaccetti, C., Bruno, A., Magnani, E., Bartolini, D., Principi, E., Dallaglio, K., Bucci, E.O., Finzi, G., Sessa, F., Noonan, D.M., et al. (2015). Effects of 5-Fluorouracil on Morphology, Cell Cycle, Proliferation, Apoptosis, Autophagy and ROS Production in Endothelial Cells and Cardiomyocytes. PLoS One 10, e0115686.
  5. Mortara L, Benest AV, Bates DO, Noonan DM. Can the co-dependence of the immune system and angiogenesis facilitate pharmacological targeting of tumours? Curr Opin Pharmacol. 2017; 35:66-74.
  6. Nuti E, Bassani B, Camodeca C, Rosalia L, Cantelmo A, Gallo C, Baci D, Bruno A, Orlandini E, Nencetti S, Noonan DM, Albini A, Rossello A. Synthesis and antiangiogenic activity study of new hop chalcone Xanthohumol analogues. Eur J Med Chem. 2017; 138:890-9.

Anno 2016

  1. Bassani B, Bartolini D, Pagani A, Principi E, Zollo M, Noonan DM, Albini A, Bruno A. Fenretinide (4-HPR) Targets Caspase-9, ERK 1/2 and the Wnt3a/beta-Catenin Pathway in Medulloblastoma Cells and Medulloblastoma Cell Spheroids. PLoS One. 2016; 11:e0154111.
  2. Bassani B, Rossi T, De Stefano D, Pizzichini D, Corradino P, Macrì N, Noonan DM, Albini A, Bruno A. Potential chemopreventive activities of a polyphenol rich purified extract from olive mill wastewater on colon cancer cells. Journal of Functional Foods. 2016; 27:236-48.
  3. Campomenosi P, Gini E, Noonan DM, Poli A, D’Antona P, Rotolo N, Dominioni L, Imperatori A. A comparison between quantitative PCR and droplet digital PCR technologies for circulating microRNA quantification in human lung cancer. BMC Biotechnol. 2016; 16:60.
  4. Gallo C, Dallaglio K, Bassani B, Rossi T, Rossello A, Noonan DM, D’Uva G, Bruno A, Albini A. Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation. Oncotarget. 2016; 7:59917-31.
  5. Principi E, Girardello R, Bruno A, Manni I, Gini E, Pagani A, Grimaldi A, Ivaldi F, Congiu T, De Stefano D, Piaggio G, de Eguileor M, Noonan DM, Albini A. Systemic distribution of single-walled carbon nanotubes in a novel model: alteration of biochemical parameters, metabolic functions, liver accumulation, and inflammation in vivo. Int J Nanomedicine. 2016; 11:4299-316.
  6. Pulze L, Bassani B, Gini E, D’Antona P, Grimaldi A, Luini A, Marino F, Noonan DM, Tettamanti G, Valvassori R, de Eguileor M. NET amyloidogenic backbone in human activated neutrophils. Clin Exp Immunol. 2016; 183:469-79.
  7. Storti P, Marchica V, Airoldi I, Donofrio G, Fiorini E, Ferri V, Guasco D, Todoerti K, Silbermann R, Anderson JL, Zhao W, Agnelli L, Bolzoni M, Martella E, Mancini C, Campanini N, Noonan DM, Petronini PG, Neri A, Aversa F, Roodman GD, Giuliani N. Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo. Leukemia. 2016.
  8. Talarico G, Orecchioni S, Dallaglio K, Reggiani F, Mancuso P, Calleri A, Gregato G, Labanca V, Rossi T, Noonan DM, Albini A, Bertolini F. Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells. Sci Rep. 2016; 6:18673.

Anno 2015

  1. Albini A, Bertolini F, Bassani B, Bruno A, Gallo C, Caraffi SG, Maramotti S, Noonan DM. Biomarkers of cancer angioprevention for clinical studies. Ecancermedicalscience. 2015; 9:600.
  2. Albini A, Briga D, Conti M, Bruno A, Farioli D, Canali S, Sogno I, D’Ambrosio G, Consonni P, Noonan DM. SANIST: a rapid mass spectrometric SACI/ESI data acquisition and elaboration platform for verifying potential candidate biomarkers. Rapid Commun Mass Spectrom. 2015; 29:1703-10.
  3. Albini A, Bruno A, Gallo C, Pajardi G, Noonan DM, Dallaglio K. Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity. Connect Tissue Res. 2015; 56:414-25.
  4. Albini A, Cavuto S, Apolone G, Noonan DM. Strategies to Prevent “Bad Luck” in Cancer. J Natl Cancer Inst. 2015; 107.
  5. Albini A, Pagani A, Pulze L, Bruno A, Principi E, Congiu T, Gini E, Grimaldi A, Bassani B, De Flora S, de Eguileor M, Noonan DM. Environmental impact of multi-wall carbon nanotubes in a novel model of exposure: systemic distribution, macrophage accumulation, and amyloid deposition. Int J Nanomedicine. 2015; 10:6133-45.
  6. Astigiano S, Morini M, Damonte P, Fraternali Orcioni G, Cassanello M, Puglisi A, Noonan DM, Bronte V, Barbieri O. Transgenic mice overexpressing arginase 1 in monocytic cell lineage are affected by lympho-myeloproliferative disorders and disseminated intravascular coagulation. Carcinogenesis. 2015; 36:1354-62.
  7. Focaccetti C, Bruno A, Magnani E, Bartolini D, Principi E, Dallaglio K, Bucci EO, Finzi G, Sessa F, Noonan DM, Albini A. Effects of 5-Fluorouracil on Morphology, Cell Cycle, Proliferation, Apoptosis, Autophagy and ROS Production in Endothelial Cells and Cardiomyocytes. PLoS One. 2015; 10:e0115686.
  8. Lococo F, Paci M, Rapicetta C, Rossi T, Sancisi V, Braglia L, Cavuto S, Bisagni A, Bongarzone I, Noonan DM, Albini A, Maramotti S. Preliminary Evidence on the Diagnostic and Molecular Role of Circulating Soluble EGFR in Non-Small Cell Lung Cancer. Int J Mol Sci. 2015; 16:19612-30.
  9. Morandi F, Horenstein AL, Chillemi A, Quarona V, Chiesa S, Imperatori A, Zanellato S, Mortara L, Gattorno M, Pistoia V, Malavasi F. CD56brightCD16- NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+ T Cell Proliferation. J Immunol. 2015 Aug 1;195(3):965-72.
  10. Mortara L, Zanellato S, Bassani B, Imperatori A, Rotolo N, Dominioni L, Albini A, Noonan DM, Bruno A. Polarization of Tumor Infiltrating Leukocytes from Innate Immunity and their role in the Pro-angiogenic Phenotype in NSCLC. J Clin Cell Immunol. 2015; 6:312.
  11. Orecchioni S, Reggiani F, Talarico G, Mancuso P, Calleri A, Gregato G, Labanca V, Noonan DM, Dallaglio K, Albini A, Bertolini F. The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells. Int J Cancer. 2015; 136:E534-44.
  12. Rossi T, Bassani B, Gallo C, Maramotti S, Noonan DM, Albini A, Bruno A. Effect of a Purified Extract of Olive Mill Waste Water on Endothelial Cell Proliferation, Apoptosis, Migration and Capillary-Like Structure in vitro and in vivo. J Bioanal Biomed. 2015; S12:006.

Anno 2014

  1. Albini, A., Rosano, C., Angelini, G., Amaro, A., Esposito, A.I., Maramotti, S., Noonan, D.M., and Pfeffer, U. (2014). Exogenous hormonal regulation in breast cancer cells by phytoestrogens and endocrine disruptors. Curr Med Chem 21, 1129-1145.
  2. Amaro, A.A., Esposito, A.I., Mirisola, V., Mehilli, A., Rosano, C., Noonan, D.M., Albini, A., Pfeffer, U., and Angelini, G. (2014). Endocrine disruptor agent nonyl phenol exerts an estrogen-like transcriptional activity on estrogen receptor positive breast cancer cells. Curr Med Chem 21, 630-640.
  3. Bruno, A., Pagani, A., Pulze, L., Albini, A., Dallaglio, K., Noonan, D.M., and Mortara, L. (2014). Orchestration of angiogenesis by immune cells. Frontiers in oncology 4, 131.
  4. Bruno, A., Pagani, A., Magnani, E., Rossi, T., Noonan, D.M., Cantelmo, A.R., and Albini, A. (2014). Inflammatory angiogenesis and the tumor microenvironment as targets for cancer therapy and prevention. Cancer Treat Res 159, 401-426.
  5. Bruno, A., Ferlazzo, G., Albini, A., and Noonan, D.M. (2014). A Think Tank of TINK/TANKs: Tumor-Infiltrating/Tumor-Associated Natural Killer Cells in Tumor Progression and Angiogenesis. J Natl Cancer Inst, 106(8):dju200.
  6. Dallaglio, K., Bruno, A., Cantelmo, A.R., Esposito, A.I., Ruggiero, L., Orecchioni, S., Calleri, A., Bertolini, F., Pfeffer, U., Noonan, D.M., et al. (2014). Paradoxic effects of metformin on endothelial cells and angiogenesis. Carcinogenesis 35, 1055-1066.
  7. Kronski, E., Fiori, M.E., Barbieri, O., Astigiano, S., Mirisola, V., Killian, P.H., Bruno, A., Pagani, A., Rovera, F., Pfeffer, U., et al. (2014). miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2. Molecular oncology 8, 581-595.
  8. Orecchioni, S., Reggiani, F., Talarico, G., Mancuso, P., Calleri, A., Gregato, G., Labanca, V., Noonan, D.M., Dallaglio, K., Albini, A., et al. (2014). The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells. Int J Cancer.
  9. Vene, R., Cardinali, B., Arena, G., Ferrari, N., Benelli, R., Minghelli, S., Poggi, A., Noonan, D.M., Albini, A., and Tosetti, F. (2014). Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress. Neoplasia 16, 710-722.

Anno 2013

  1. L. Mortara, P. Orecchia, P. Castellani, L. Borsi, B. Carnemolla, E. Balza (2013). Schedule-dependent therapeutic efficacy of L19mTNF-a and Melphalan combined with Gemcitabine. Cancer Med. 2(4):478-487.
  2. A. Imperatori, M. Castiglioni, L. Mortara, E. Nardecchia, N. Rotolo (2013). The challenge of prognostic markers in pleural mesothelioma. J Thorac Dis. 5(3):205-206.
  3. A. Bruno, C. Focaccetti, A. Pagani, A.S. Imperatori, M. Spagnoletti, N. Rotolo, A.R. Cantelmo, F. Franzi, C. Capella, G. Ferlazzo, L. Mortara, A. Albini, D.M. Noonan (2013). The proangiogenic phenotype of natural killer cells in patients with non-small cell lung cancer. Neoplasia. 15:133-142.
  4. Puccio, G., Brambilla, P., Conti, M., Bartolini, D., Noonan, D., and Albini, A. (2013). Surface-activated chemical ionization-electrospray mass spectrometry in the analysis of urinary thiodiglycolic acid. Rapid Commun Mass Spectrom 27, 476-480.

Papers Archive

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